Integrative bulk and single-cell transcriptomic analyses reveal nucleus pulposus cell fibrosis as a therapeutic target in intervertebral disc degeneration and identify quercetin as a potential antifibrotic agent | Literature Database for Quercetin, Rutin, Isorhamnetin, and Their Related Compounds | Alps Pharmaceutical Ind. Co.,Ltd.

Literature Database for Quercetin, Rutin, Isorhamnetin, and Their Related Compounds

Integrative bulk and single-cell transcriptomic analyses reveal nucleus pulposus cell fibrosis as a therapeutic target in intervertebral disc degeneration and identify quercetin as a potential antifibrotic agent

Authors:: Peilin He; Jun Tao; Guo Li; Ye Mu; Rong Hu; Junming Chen; Wenqi Feng

Reference:: Naunyn-Schmiedeberg's Archives of Pharmacology; 2026; 399; in press

DOI:: 10.1007/s00210-026-05035-z

See Abstract

Key Words:: Intervertebral disc degeneration; nucleus pulposus cells; fibrosis; TGF-β; TGF-β receptor 2; quercetin; rats; animal experiments; RNA sequencing; transcriptome analysis

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