Literature Database for Quercetin, Rutin, Isorhamnetin, and Their Related Compounds

Here we provide a literature database for flavonoids, focused upon quercetin, rutin, isorhamnetin, and their related compounds. Original papers and reviews about in vitro, in vivo, and clinical pharmacologies are contained here.

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Result:: 1-10 Hits of 10

Senloytics, dasatinib plus quercetin, reduce kidney inflammation, senescent cell abundance, and injury while restoring geroprotective factors in murine diabetic kidney disease

Authors:: Xiaohui Bian; Zachary K. Snow; Caroline J. Zinn; Anastasia L. Bratulin; Khaled M. Elhusseiny; Tamar Tchkonia; James L. Kirkland; Yi Zhu; Sundeep Khosla; Seo Rin Kim; Lilach O. Lerman; LaTonya J. Hickson

Reference:: eBioMedicine; 2026; 124; 106124

DOI:: 10.1016/j.ebiom.2026.106124

See Abstract

A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer’s disease

Authors:: Courtney L. Millar; Ike Iloputaife; Kathryn Baldyga; Amani M. Norling; Afroditi Boulougoura; Theodoros Vichos; Tamara Tchkonia; Aaron Deisinger; Tamar Pirtskhalava; James L. Kirkland; Thomas G. Travison; Lewis A. Lipsitz

Reference:: eBioMedicine; 2025; 113; 105612

DOI:: 10.1016/j.ebiom.2025.105612

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Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial

Authors:: Joshua N. Farr; Elizabeth J. Atkinson; Sara J. Achenbach; Tammie L. Volkman; Amanda J. Tweed; Stephanie J. Vos; Ming Ruan; Jad Sfeir; Matthew T. Drake; Dominik Saul; Madison L. Doolittle; Irina Bancos; Kai Yu; Tamara Tchkonia; Nathan K. LeBrasseur; James L. Kirkland; David G. Monroe; Sundeep Khosla

Reference:: Nature Medicine; 2024; 30; 2605–2612

DOI:: 10.1038/s41591-024-03096-2

See Abstract

Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial

Reference:: Nature Medicine; 2023; 29; 2481–2488

DOI:: 10.1038/s41591-023-02543-w

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Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

Authors:: Jamie N. Justice; Anoop M. Nambiar; Tamar Tchkonia; Nathan K. LeBrasseur; Rodolfo Pascual; Shahrukh K. Hashmi; Larissa Prata; Michal M. Masternak; Stephen B. Kritchevsky; Nicolas Musi; James L. Kirkland

Reference:: eBioMedicine; 2019; 40; 554-563

DOI:: 10.1016/j.ebiom.2018.12.052

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Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin

Authors:: Seo Rin Kim; Kai Jiang; Mikolaj Ogrodnik; Xiaojun Chen; Xiang-Yang Zhu; Hannah Lohmeier; Leena Ahmed; Hui Tang; Tamara Tchkonia; LaTonya J. Hickson; James L. Kirkland; Lilach O. Lerman

Reference:: Translational Research; 2019; 213; 112-123

DOI:: 10.1016/j.trsl.2019.07.005

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The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Reference:: Aging Cell; 2015; 14; 644-658

DOI:: 10.1111/acel.12344

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Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Authors:: LaTonya J. Hickson; Larissa G.P. Langhi Prata; Shane A. Bobart; Tamara K. Evans; Nino Giorgadze; Shahrukh K. Hashmi; Sandra M. Herrmann; Michael D. Jensen; Qingyi Jia; Kyra L. Jordan; Todd A. Kellogg; Sundeep Khosla; Daniel M. Koerber; Anthony B. Lagnado; Donna K. Lawson; Nathan K. LeBrasseur; Lilach O. Lerman; Kathleen M. McDonald; James L. Kirkland

Reference:: eBioMedicine; 2019; 47; 446-456

DOI:: 10.1016/j.ebiom.2019.08.069

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Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice

Authors:: Tatiana Dandolini Saccon; Ravinder Nagpal; Hariom Yadav; Marcelo Borges Cavalcante; Allancer Divino de Carvalho Nunes; Augusto Schneider; Adam Gesing; Brian Hughes; Matthew Yousefzadeh; Tamar Tchkonia; James L. Kirkland; Laura J. Niedernhofer; Paul D. Robbins; Michal M. Masternak

Reference:: The Journals of Gerontology: Series A; 2021; 76; 1895–1905

DOI:: 10.1093/gerona/glab002

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Quercetin Reverses Cardiac Systolic Dysfunction in Mice Fed with a High-Fat Diet: Role of Angiogenesis

Authors:: Shasha Yu; Seo Rin Kim; Kai Jiang; Mikolaj Ogrodnik; Xiang Y. Zhu; Christopher M. Ferguson; Tamara Tchkonia; Amir Lerman; James L. Kirkland; Lilach O. Lerman

Reference:: Oxidative Medicine and Cellular Longevity; 2021; 2021; 8875729

DOI:: 10.1155/2021/8875729

See Abstract