Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease
- Reference:
- Biogerontology
- 2024
- 25
- 71–82
- DOI:
- 10.1007/s10522-023-10068-5
Literature Database for Quercetin, Rutin, Isorhamnetin, and Their Related Compounds
Here we provide a literature database for flavonoids, focused upon quercetin, rutin, isorhamnetin, and their related compounds. Original papers and reviews about in vitro, in vivo, and clinical pharmacologies are contained here.
Search
- Result:
- 11-20 Hits of 43
Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial
- Authors:
- Mitzi M. Gonzales
- Valentina R. Garbarino
- Tiffany F. Kautz
- Juan Pablo Palavicini
- Marisa Lopez-Cruzan
- Shiva Kazempour Dehkordi
- Julia J. Mathews
- Habil Zare
- Peng Xu
- Bin Zhang
- Crystal Franklin
- Mohamad Habes
- Suzanne Craft
- Ronald C. Petersen
- Tamara Tchkonia
- James L. Kirkland
- Arash Salardini
- Sudha Seshadri
- Nicolas Musi
- Miranda E. Orr
- Reference:
- Nature Medicine
- 2023
- 29
- 2481–2488
- DOI:
- 10.1038/s41591-023-02543-w
Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy
- Authors:
- Hanxin Liu
- Qixia Xu
- Halidan Wufuer
- Zi Li
- Rong Sun
- Zhirui Jiang
- Xuefeng Dou
- Qiang Fu
- Judith Campisi
- Yu Sun
- Reference:
- Aging Cell
- 2023
- 22
- e13921
- DOI:
- 10.1111/acel.13921
Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells
- Reference:
- PLoS ONE
- 2018
- 13
- e0190374
- DOI:
- 10.1371/journal.pone.0190374
Human rotator cuff tears demonstrate an age-dependent increase in markers of cellular senescence and selective removal of senescent cells with dasatinib+quercetin increases genetic expression of COL1A1 in vitro
- Authors:
- Benjamin C. Hawthorne
- Ian J. Wellington
- Joshua T. Sabitsky
- Kyle V. Murphy
- Owen P. Karsmarski
- Rohin O. Thomas
- Matthew R. LeVasseur
- Michael R. Mancini
- Maxwell T. Trudeau
- Sagar Gulati
- Mary Beth R. McCarthy
- Mark P. Cote
- Ming Xu
- Augustus D. Mazzocca
- Reference:
- Arthroscopy: The Journal of Arthroscopic & Related Surgery
- 2024
- 40
- 34-44
- DOI:
- 10.1016/j.arthro.2023.05.036
A short dasatinib and quercetin treatment is sufficient to reinstate potent adult neuroregenesis in the aged killifish
- Authors:
- Jolien Van houcke
- Valerie Mariën
- Caroline Zandecki
- Rajagopal Ayana
- Elise Pepermans
- Kurt Boonen
- Eve Seuntjens
- Geert Baggerman
- Lutgarde Arckens
- Reference:
- npj Regenerative Medicine
- 2023
- 8
- 31
- DOI:
- 10.1038/s41536-023-00304-4
Sexual dimorphic metabolic and cognitive responses of C57BL/6 mice to Fisetin or Dasatinib and quercetin cocktail oral treatment
- Authors:
- Yimin Fang
- David Medina
- Robert Stockwell
- Sam McFadden
- Kathleen Quinn
- Mackenzie R. Peck
- Andrzej Bartke
- Kevin N. Hascup
- Erin R. Hascup
- Reference:
- GeroScience
- 2023
- 45
- 2835–2850
- DOI:
- 10.1007/s11357-023-00843-0
Senolytic Treatment with Dasatinib and Quercetin Does Not Improve Overall Influenza Responses in Aged Mice
- Authors:
- Blake Torrance
- Andreia N. Cadar
- Dominique E. Martin
- Hunter A. Panier
- Erica C. Lorenzo
- Jenna M. Bartley
- Ming Xu
- Laura Haynes
- Reference:
- Frontiers in Aging
- 2023
- 4
- 1212750
- DOI:
- 10.3389/fragi.2023.1212750
Long-term dasatinib plus quercetin effects on aging outcomes and inflammation in nonhuman primates: implications for senolytic clinical trial design
- Authors:
- Alistaire D. Ruggiero
- Ravichandra Vemuri
- Megan Blawas
- Masha Long
- Darla DeStephanis
- Abigail G. Williams
- Haiying Chen
- Jamie N. Justice
- Shannon L. Macauley
- Steven M. Day
- Kylie Kavanagh
- Reference:
- GeroScience
- 2023
- 45
- 2785–2803
- DOI:
- 10.1007/s11357-023-00830-5
Dasatinib and quercetin increase testosterone and sperm concentration in mice
- Reference:
- Physiology International
- 2023
- 110
- 121–134
- DOI:
- 10.1556/2060.2023.00192